The reference site for Doxepin

Doxepin is a tricyclic antidepressant marketed worldwide. It is marketed under many brand names worldwide.

WHAT IS Doxepin?

Doxepin is in a class of drugs called tricyclic antidepressants. It works by affecting chemicals in the brain that may become unbalanced and cause depression.

Doxepin is used to relieve symptoms of depression and anxiety such as feelings of sadness, worthlessness, or guilt, as well as loss of interest in daily activities, changes in appetite, tiredness, sleeping too much, insomnia, and thoughts of death or suicide.

 

Brand Name(s): Adapin, Sinequan
CAS nº: 1668-19-5
(dox‘ e pin)

 

Product Info

The sections below will provide you with more specific information and guidelines related to doxepin and its correct use. Please read them carefully.

FDA Information

Doxepin was originally approved by the FDA in 1969. A topical formulation of doxepin (Zonalon®) was approved for pruritus associated with eczema in 1994.

On October 15, 2004 the FDA directed manufacturers of all antidepressants to include a Black Box warning, expanded warning statements, and clinical trial results detailing the increased risk of suicidality in children and adolescents.

Why is this medication prescribed?

Doxepin is in a class of drugs called tricyclic antidepressants. This medication affects chemicals in the brain that may become unbalanced and cause depression.

Doxepin is used to relieve symptoms of depression and anxiety such as feelings of sadness, worthlessness, or guilt; loss of interest in daily activities; changes in appetite; tiredness; sleeping too much; insomnia, and thoughts of death or suicide.

Other uses for this medicine

Doxepin is also used occasionally to treat chronic pain, peptic ulcer disease, and some skin conditions.

However, it is important that you talk to your doctor about the possible risks of using this drug for your particular condition.

Dosage and using this medicine

Doxepin comes as a capsule or concentrate (oral liquid) to be taken by mouth. The capsule should never be broken or split, as some forms of this medication contain dye extracts that can stain the teeth.

Doxepin may be taken several times a day or in one daily dose (usually at bedtime).

Take doxepin exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Doxepin concentrate (oral liquid) comes with a specially marked dropper for measuring the dose. Ask your pharmacist to show you how to use the dropper.

Dilute the concentrate in 4 ounces (120 ml) of water, whole or skimmed milk, or orange, grapefruit, tomato, prune, or pineapple juice just before taking it. Do not mix it with carbonated beverages (soft drinks). If you take doxepin concentrate and methadone syrup, the two liquids can be mixed together with Gatorade, lemonade, orange juice, Tang, or water but not with grape juice.

Continue to take doxepin even if you feel well. Do not stop taking doxepin without talking to your doctor, especially if you have taken large doses for a long time. Your doctor probably will want to decrease your dose gradually. This drug must be taken regularly for a few weeks before its full effect is felt.

What special precautions should I follow?

Before taking Doxepin:

Tell your doctor if you have liver disease, kidney disease, asthma, thyroid disease, diabetes, stomach or intestinal problems, high blood pressure or heart disease, had a heart attack in the last 6 weeks, an enlarged prostate or difficulty urinating, or glaucoma.

Do not take doxepin if you have taken a monoamine oxidase inhibitor such as isocarboxazid (Marplan®), phenelzine (Nardil®), or tranylcypromine (Parnate®) within the last 14 days.

Doxepin may increase the effects of other drugs that cause drowsiness, including other antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, and muscle relaxants. Inform your doctor about all medicines that you are taking, and do not take any other prescription or over-the-counter medicines without first talking to your doctor.

You may not be able to take doxepin, or you may require a dosage adjustment or special monitoring during therapy, if you have any of the conditions listed above.

While you are taking doxepin you may need to be monitored for worsening symptoms of depression and/ or suicidal thoughts at the start of therapy or when doses are changed. This concern about the increased risk of suicidal thoughts or behaviors may be greater if you are 18 years of age or younger and are taking doxepin. In patients younger than 18 years, the period of risk may extend beyond start of therapy or when doses are changed. Your doctor may want you to monitor for the following symptoms: anxiety, panic attacks, difficulty sleeping, irritability, hostility, impulsivity, severe restlessness, and mania (mental and/ or physical hyperactivity). These symptoms may be associated with the development of worsening symptoms of depression and/ or suicidal thoughts or actions. Contact your healthcare provider if you develop any new or worsening mental health symptoms during treatment with doxepin.

It is not known whether doxepin will be harmful to an unborn baby. Do not take doxepin without first talking to your doctor if you are pregnant or could become pregnant during treatment.

Doxepin passes into breast milk and may affect a nursing baby. Do not take doxepin without first talking to your doctor if you are breast-feeding a baby.

If you are over 60 years of age, you may be more likely to experience side effects such as drowsiness, dizziness, unsteadiness, feeling uncoordinated, and low blood pressure. Your doctor may prescribe a lower dose of this medication.

Use cautiously when driving, operating machinery, or performing other hazardous activities. Doxepin may cause drowsiness or dizziness. If you experience drowsiness or dizziness, please avoid these activities.

Dizziness is likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall.

Additionally, use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking doxepin.

What should I do if I forget a dose?

Take the missed dose as soon as you remember. If it is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed.

Do not take a double dose of this medication unless otherwise directed by your doctor.

[/expand

Possible side effects from using doxepin may include:

rapid heart rate
blurred vision
urinary retention (difficulty urinating)
dry mouth
constipation
weight gain or loss

Tell your doctor if any of these symptoms are severe or do not go away:

drowsiness or dizziness
dry mouth and eyes
constipation
mild tremor
sweating
mild agitation, weakness, or headache
ringing in the ears
nausea
loss of weight or appetite

If you experience any of the following symptoms, call your doctor immediately:

an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, face, or tongue; or hives)
seizures
a fast or irregular heartbeat
a heart attack
high blood pressure (blurred vision, severe headache)
difficulty urinating
fever with increased sweating, muscle stiffness, or severe muscle weakness

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Throw away any medication that is outdated or no longer needed. If required, please talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of an overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include:

seizures
confusion
drowsiness
agitation
hallucinations
low blood pressure (dizziness, fatigue, fainting)

Product Images

PICTURES OF DOXEPIN PILLS

Below you will find images and specific information on the principal types of doxepin that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: DOXEPIN
Strength(s): 10 mg
Imprint: PAR 217
Manufacturer: PAR PHARMACEUTICAL

Name: DOXEPIN
Strength(s): 25 mg
Imprint: Par 218
Manufacturer: PAR PHARMACEUTICAL

Name: DOXEPIN
Strength(s): 25 mg
Imprint: MYLAN 3125
Manufacturer: MYLAN PHARMACEUTICALS

Name: DOXEPIN
Strength(s): 50 mg
Imprint: MYLAN 4250
Manufacturer: MYLAN PHARMACEUTICALS

Name: DOXEPIN
Strength(s): 75 mg
Imprint: MYLAN 5375
Distributor: UDL LABORATORIES INC.

Name: DOXEPIN
Strength(s): 100 mg
Imprint: MYLAN 6410
Distributor: MAJOR PHARMACEUTICALS INC.

Contact us